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A Chemical Perspective of Pharmacology and Toxicology
Annual Review of Pharmacology and Toxicology ( IF 11.2 ) Pub Date : 2018-01-08 00:00:00 , DOI: 10.1146/annurev-pharmtox-010617-053205
Arthur K. Cho 1
Affiliation  

My chemical training provided a somewhat different perspective of biolo-gical problems, in the problem itself and approaches to its solution. I was fortunate to have in my laboratory postdocs and students who shared this perspective and used appropriate tools to address problems in amphetamine pharmacology and air pollution toxicology. These apparently disparate areas of research shared two chemical reactions: prooxidant-based generation of reactive oxygen and formation of covalent bonds between electrophiles and biological nucleophiles. This article is an attempt to summarize that research and to identify those individuals who made the contributions.

中文翻译:


药理毒理学的化学观点

我的化学培训在问题本身和解决方法上对生物学问题提出了不同的看法。我很幸运在实验室的博士后和同学中分享了这一观点,并使用适当的工具解决了苯丙胺药理学和空气污染毒理学的问题。这些明显不同的研究领域共有两个化学反应:基于氧化剂的反应性氧的生成以及亲电子试剂与生物亲核试剂之间共价键的形成。本文旨在总结该研究并确定做出贡献的个人。

更新日期:2018-01-08
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