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Repairing Mitochondrial Dysfunction in Disease
Annual Review of Pharmacology and Toxicology ( IF 11.2 ) Pub Date : 2018-01-08 00:00:00 , DOI: 10.1146/annurev-pharmtox-010716-104908
Vincenzo Sorrentino 1 , Keir J. Menzies 2 , Johan Auwerx 1
Affiliation  

Mitochondria are essential organelles for many aspects of cellular homeostasis, including energy harvesting through oxidative phosphorylation. Alterations of mitochondrial function not only impact on cellular metabolism but also critically influence whole-body metabolism, health, and life span. Diseases defined by mitochondrial dysfunction have expanded from rare monogenic disorders in a strict sense to now also include many common polygenic diseases, including metabolic, cardiovascular, neurodegenerative, and neuromuscular diseases. This has led to an intensive search for new therapeutic and preventive strategies aimed at invigorating mitochondrial function by exploiting key components of mitochondrial biogenesis, redox metabolism, dynamics, mitophagy, and the mitochondrial unfolded protein response. As such, new findings linking mitochondrial function to the progression or outcome of this ever-increasing list of diseases has stimulated the discovery and development of the first true mitochondrial drugs, which are now entering the clinic and are discussed in this review.

中文翻译:


修复疾病中的线粒体功能障碍

线粒体是细胞动态平衡许多方面必不可少的细胞器,包括通过氧化磷酸化收集能量。线粒体功能的改变不仅影响细胞代谢,而且严重影响全身代谢,健康和寿命。由线粒体功能障碍定义的疾病已从严格意义上的罕见单基因疾病扩展到现在也包括许多常见的多基因疾病,包括代谢,心血管,神经退行性疾病和神经肌肉疾病。这导致人们对新的治疗和预防策略进行了深入的研究,目的是通过利用线粒体生物发生,氧化还原代谢,动力学,线粒体和线粒体展开的蛋白质反应等关键成分来增强线粒体功能。因此,

更新日期:2018-01-08
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