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The Conducted Vasomotor Response: Function, Biophysical Basis, and Pharmacological Control
Annual Review of Pharmacology and Toxicology ( IF 11.2 ) Pub Date : 2018-01-08 00:00:00 , DOI: 10.1146/annurev-pharmtox-010617-052623
Donald G. Welsh 1 , Cam Ha T. Tran 2 , Bjorn O. Hald 3 , Maria Sancho 1
Affiliation  

Arterial tone is coordinated among vessel segments to optimize nutrient transport and organ function. Coordinated vasomotor activity is remarkable to observe and depends on stimuli, sparsely generated in tissue, eliciting electrical responses that conduct lengthwise among electrically coupled vascular cells. The conducted response is the focus of this topical review, and in this regard, the authors highlight literature that advances an appreciation of functional significance, cellular mechanisms, and biophysical principles. Of particular note, this review stresses that conduction is enabled by a defined pattern of charge movement along the arterial wall as set by three key parameters (tissue structure, gap junctional resistivity, and ion channel activity). The impact of disease on conduction is carefully discussed, as are potential strategies to restore this key biological response and, along with it, the match of blood flow delivery with tissue energetic demand.

中文翻译:


进行的血管舒缩反应:功能,生物物理基础和药理控制

血管张力在各个血管段之间进行协调,以优化营养物质的运输和器官功能。观察到协调的血管舒缩活性是显着的,并且依赖于稀疏地在组织中产生的刺激,从而引起在电耦合的血管细胞之间纵向传导的电响应。进行的反应是本主题综述的重点,在这方面,作者重点介绍了一些文献,这些文献推动了人们对功能重要性,细胞机制和生物物理原理的认识。特别要注意的是,这篇综述强调了传导是通过由三个关键参数(组织结构,间隙连接电阻率和离子通道活性)设定的沿动脉壁的电荷运动模式来实现的。仔细讨论了疾病对传导的影响,

更新日期:2018-01-08
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