In the present study, ibuprofen-loaded nano metal–organic frameworks (NMOFs) {Cu₂(1,4-bdc)₂(dabco)}_n and {Cu₂(1,4-bdc-NH₂)₂(dabco)}_n (bdc=benzenedicarboxylic acid, and dabco=diazabicyclooctane) were synthesized by ball-milling at room temperature in 2 h. The produced drug-loaded Cu-NMOFs were studied as ibuprofen drug delivery system and exhibited well-defined drug release behavior, exceptionally high drug loading capacities and the ability to entrap the model drug. The loading efficiency for ibuprofen was determined about 50.54% and 50.27%, respectively. The drug release of NMOFs was also monitored, and all of the loaded drug was released in 1 day. The NMOFs were characterized by FT-IR spectroscopy, X-ray powder diffraction (XRPD), thermogravimetric analysis (TGA), SEM (scanning electron microscopy), transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy (EDS), inductively coupled plasma (ICP), UV–vis spectroscopy and N₂ adsorption porosimetry (BET&BJH).

在本研究中，布洛芬负载的纳米金属有机框架（NMOF）{Cu ₂（1,4- bdc）₂（dabco）} _n和{Cu ₂（1,4- bdc -NH ₂）₂（dabco） } _n（bdc ＝苯二甲酸，和dabco ＝二氮杂双环辛烷）通过在室温下在2小时内球磨合成。所生产的载有药物的Cu-NMOF作为布洛芬药物传递系统进行了研究，并显示出明确的药物释放行为，极高的药物载量和截留模型药物的能力。布洛芬的负载效率分别确定为约50.54％和50.27％。还监测了NMOF的药物释放，并且所有负载药物均在1天之内释放。NMOF通过FT-IR光谱，X射线粉末衍射（XRPD），热重分析（TGA），SEM（扫描电子显微镜），透射电子显微镜（TEM），能量色散X射线光谱（EDS），电感耦合等离子体（ICP），紫外可见光谱和N ₂ 吸附孔隙率法（BET＆BJH）。