[¹⁸F]Fluorodeoxyglucose-PET/CT (¹⁸F-FDG-PET/CT) imaging has been invaluable for visualizing metabolically active adipose tissues in humans with potential anti-diabetic and anti-obesity effects. To explore whether mice display human-like fat depots in anatomically comparable regions, we mapped fat depots using glucose or fatty acid imaging tracers, such as ¹⁸F-FDG through PET/CT or [^123/125I]-β-methyl-p-iodophenyl-pentadecanoic acid with SPECT/CT imaging, to analogous depots in mice. Using this type of image analysis with both probes, we define a large number of additional areas of high metabolic activity corresponding to novel fat pads. Histological and gene expression analyses validate these regions as bona fide fat pads. Our findings indicate that fat depots of rodents show a high degree of topological similarity to those of humans. Studies involving both glucose and lipid tracers indicate differential preferences for these substrates in different depots and also suggest that fatty acid-based visualized approaches may reveal additional brown adipose tissue and beige depots in humans.

中文翻译：

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脂肪组织图谱：啮齿动物中类人 BAT 和米色库的图像引导识别。

[ ¹⁸ F] 氟脱氧葡萄糖-PET/CT ( ¹⁸ F-FDG-PET/CT) 成像对于可视化具有潜在抗糖尿病和抗肥胖作用的人体代谢活跃的脂肪组织非常宝贵。为了探索小鼠是否在解剖学可比区域显示类似人类的脂肪库，我们使用葡萄糖或脂肪酸成像示踪剂绘制了脂肪库，例如¹⁸ F-FDG 通过 PET/CT 或 [ ^123/125I]-β-甲基-对碘苯基-十五烷酸与 SPECT/CT 成像，到小鼠中的类似库。使用两种探针的这种类型的图像分析，我们定义了大量与新型脂肪垫相对应的高代谢活动的附加区域。组织学和基因表达分析证实这些区域是真正的脂肪垫。我们的研究结果表明，啮齿动物的脂肪库与人类的脂肪库具有高度的拓扑相似性。涉及葡萄糖和脂质示踪剂的研究表明，这些底物在不同库中的偏好不同，还表明基于脂肪酸的可视化方法可能会揭示人类中额外的棕色脂肪组织和米色库。