A novel metal-free one-pot protocol for the effective and efficient synthesis of 3-phosphinoylbenzofurans via a phospha-Michael addition/cyclization of H-phosphine oxides and in situ generated ortho-quinone methides is described. Based on the expeditious construction of C(sp²)–P bonds, asymmetric synthesis of optically pure 3-phosphinoylbenzofurans containing chiral P-stereogenic center has also been probed by using chiral R_P-(−)-menthyl phenylphosphine oxide.

中文翻译：

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H-膦氧化物的磷-迈克尔加成/环化反应和原位生成的邻醌甲基甲烷的无金属一锅合成3-膦酰基苯并呋喃

描述了一种新颖的无金属一锅方案，该方案通过H-膦氧化物的磷化-迈克尔加成/环化作用和原位生成的邻醌甲基化物来有效和高效地合成3-膦酰基苯并呋喃。基于C（sp ²）-P键的快速构建，还通过使用手性R _P -（-）-薄荷基苯基膦氧化物探索了含手性P-立体异构中心的光学纯3-膦酰基苯并呋喃的不对称合成。