Abstract Based on the overexpression of specific receptors on tumor cells, active targeting nanomedicines have been developed with the ability to efficiently deliver imaging agents in the tumor area or anticancer drugs into tumor cells via receptor-mediated endocytosis. Nevertheless, the efficacy of single-ligand nanomedicines is still limited due to the complexity of the tumor microenvironment. In recent years, dual-ligand nanomedicines have attracted a lot of interest, because these nanomedicines endowed with versatile functions, have the potential to improve the efficacy of tumor-targeted delivery. In this review, an overview of various dual-ligand nanomedicines for tumor targeted therapy will be presented, the role of cell penetrating peptides in combination with targeting ligands will be discussed and factors that affect the targeting efficacy of dual-ligand nanomedicines will be evaluated.

中文翻译：

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用于增强肿瘤治疗的双靶向纳米药物

摘要 基于肿瘤细胞上特异性受体的过度表达，已经开发出主动靶向纳米药物，能够通过受体介导的内吞作用将显像剂或抗癌药物有效地输送到肿瘤区域。然而，由于肿瘤微环境的复杂性，单配体纳米药物的疗效仍然有限。近年来，双配体纳米药物引起了很多人的兴趣，因为这些纳米药物具有多种功能，有可能提高肿瘤靶向给药的疗效。在这篇综述中，将概述用于肿瘤靶向治疗的各种双配体纳米药物，