4‐Trifluoromethyl‐3‐oxo‐β‐lactams were unexpectedly transformed into 2‐[(2,2‐difluorovinyl)amino]‐2‐oxoacetates as major products, accompanied by minor amounts of 2‐oxo‐2‐[(2,2,2‐trifluoroethyl)amino]acetates, upon treatment with alkyl halides and triethylamine in DMSO. This peculiar C3−C4 bond fission reactivity was investigated in‐depth, from both an experimental and a computational point of view, in order to shed light on the underlying reaction mechanism.

中文翻译：

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通过4-三氟甲基-3-氧代-β-内酰胺中意外的C3-C4键裂变形成氟化酰胺基酯

4-三氟甲基-3-氧代-β-内酰胺意外地转化为2-[（（2,2-二氟乙烯基）氨基] -2-氧代乙酸酯作为主要产物，并伴有少量的2-氧代-2-[[2， 2,2-三氟乙基）氨基]乙酸酯，在DMSO中用卤代烷和三乙胺处理。从实验和计算的角度对这种奇特的C3-C4键裂变反应性进行了深入研究，以阐明潜在的反应机理。