A flexible polyaniline-based bioelectronic patch†,Biomaterials Science

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A flexible polyaniline-based bioelectronic patch†
Biomaterials Science ( IF 5.8 ) Pub Date : 2018-01-09 00:00:00 , DOI: 10.1039/c7bm00880e
Chen Cui _{1,

2,

3,

4} , Nastaran Faraji _{1,

2,

3,

4} , Antonio Lauto _{4,

5,

6,

7} , Lorenzo Travaglini _{1,

2,

3,

4} , Joanne Tonkin _{8,

9,

10,

11} , David Mahns _{4,

5,

6,

7} , Eleanor Humphrey _{8,

9,

10,

11} , Cesare Terracciano _{8,

9,

10,

11} , J. Justin Gooding _{2,

3,

4,

12,

13} , Jan Seidel _{1,

2,

3,

4} , Damia Mawad _{1,

2,

3,

4,

13}

Affiliation

Bioelectronic materials based on conjugated polymers are being developed in the hope to interface with electroresponsive tissues. We have recently demonstrated that a polyaniline chitosan patch can efficiently electro-couple with cardiac tissue modulating its electrophysiology. As a promising bioelectronic material that can be tailored to different types of devices, we investigate here the impact of varying the synthesis conditions and time of the in situ polymerization of aniline (An) on the sheet resistance of the bioelectronic patch. The sheet resistance increases significantly for samples that have either the lowest molar ratio of oxidant to monomer or the highest molar ratio of dopant to monomer, while the polymerization time does not have a significant effect on the electrical properties. Conductive atomic force microscopy reveals that the patch with the lowest sheet resistance has a connected network of the conductive phase. In contrast, patches with higher sheet resistances exhibit conductive areas of lower current signals or isolated conductive islands of high current signals. Having identified the formulation that results in patches with optimal electrical properties, we used it to fabricate patches that were implanted in rats for two weeks. It is shown that the patch retains an electroactive nature, and only mild inflammation is observed with fibrous tissue encapsulating the patch.

中文翻译：

基于柔性聚苯胺的生物电子贴片†

正在开发基于共轭聚合物的生物电子材料，以期与电响应性组织接触。最近，我们证明了聚苯胺壳聚糖贴剂可以有效地与心脏组织进行电耦合，从而调节其电生理。作为可以用于不同类型设备的量身定制的有前途的生物电子材料，我们在这里研究改变合成条件和原位时间的影响苯胺（An）的聚合对生物电子贴剂的薄层电阻的影响。对于具有最低的氧化剂与单体的摩尔比或最高的掺杂剂与单体的摩尔比的样品，薄层电阻显着增加，而聚合时间对电性能没有显着影响。导电原子力显微镜显示，具有最低薄层电阻的贴片具有导电相的连接网络。相反，具有较高薄层电阻的贴片具有较低电流信号的导电区域或较高电流信号的隔离的导电岛。确定了可产生具有最佳电性能贴片的配方后，我们将其用于制造可植入大鼠体内两周的贴片。

更新日期：2018-01-09

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