Zika virus (ZIKV) is an enveloped, icosahedral flavivirus that has structural and functional similarities to other human flavivirus pathogens such as dengue (DENV), West Nile (WNV) and Japanese encephalitis (JEV) viruses. ZIKV infections have been linked to fetal microcephaly and the paralytic Guillain–Barré syndrome. This review provides a comparative structural analysis of the assembly, maturation and host-cell entry of ZIKV with other flaviviruses, especially DENV. We also discuss the mechanisms of neutralization by antibodies.

中文翻译：

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寨卡病毒和其他黄病毒的结构生物学。

Zika病毒（ZIKV）是一种包膜的二十面体黄病毒，其结构和功能与其他人类黄病毒病原体（例如登革热（DENV），西尼罗河（WNV）和日本脑炎（JEV）病毒）相似。ZIKV感染与胎儿小头畸形和麻痹性格林-巴雷综合征有关。这篇综述提供了ZIKV与其他黄病毒，尤其是DENV的组装，成熟和宿主细胞进入的比较结构分析。我们还讨论了抗体中和的机制。