Using Chemical Synthesis To Study and Apply Protein Glycosylation,Biochemistry

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Using Chemical Synthesis To Study and Apply Protein Glycosylation
Biochemistry ( IF 2.9 ) Pub Date : 2018-01-16 00:00:00 , DOI: 10.1021/acs.biochem.7b01055
Patrick K. Chaffey ₁ , Xiaoyang Guan ₁ , Yaohao Li ₁ , Zhongping Tan ₁

Affiliation

Protein glycosylation is one of the most common post-translational modifications and can influence many properties of proteins. Abnormal protein glycosylation can lead to protein malfunction and serious disease. While appreciation of glycosylation’s importance is growing in the scientific community, especially in recent years, a lack of homogeneous glycoproteins with well-defined glycan structures has made it difficult to understand the correlation between the structure of glycoproteins and their properties at a quantitative level. This has been a significant limitation on rational applications of glycosylation and on optimizing glycoprotein properties. Through the extraordinary efforts of chemists, it is now feasible to use chemical synthesis to produce collections of homogeneous glycoforms with systematic variations in amino acid sequence, glycosidic linkage, anomeric configuration, and glycan structure. Such a technical advance has greatly facilitated the study and application of protein glycosylation. This Perspective highlights some representative work in this research area, with the goal of inspiring and encouraging more scientists to pursue the glycosciences.

中文翻译：

使用化学合成研究和应用蛋白质糖基化

蛋白质糖基化是最常见的翻译后修饰之一，可影响蛋白质的许多特性。蛋白质糖基化异常可导致蛋白质功能异常和严重疾病。尽管在科学界尤其是近年来对糖基化的重要性的认识在不断提高，但缺乏具有明确的聚糖结构的均质糖蛋白使人们难以在定量水平上理解糖蛋白的结构与其性质之间的相关性。这对糖基化的合理应用和优化糖蛋白特性一直是一个重大限制。经过化学家的不懈努力，现在可以使用化学合成方法生产氨基酸序列有系统性变化的均一糖型的集合，糖苷键，异头构型和聚糖结构。这样的技术进步极大地促进了蛋白质糖基化的研究和应用。该观点重点介绍了该研究领域的一些代表性工作，目的是激发和鼓励更多的科学家从事糖科学。

更新日期：2018-01-16

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