Novel in-situ formable and fibrils-reinforced polysaccharide-based composite hydrogels with dual healing ability were prepared by a facile, one-pot approach with maleilated chitosan (CS-MA) and thiol derivatised sodium alginate (SA-SH), via Michael addition reaction and ionic interaction. The unique fibrils network working as reinforcement fillers were attributed to the electrostatic interaction of CS-MA with SA-SH. This CS-MA/SA-SH composite hydrogel can self-heal cracks through dynamic disulfide exchange in 12 h at 37 °C without any external intervention. Noteworthy, fast healing ability inside hydrogels or with porous scaffolds within 1 min can be obtained via the introduction of calcium ions. Moreover, tunable shapes can also be obtained via dual cross-linking, providing advantages to optimize the fibrils-reinforced composite gels system for more biomedical applications. In addition, cell viability and proliferation showed that both of the gels before and after healing with Ca²⁺ possessed good cytocompatibility.

通过迈克尔·加成法，采用马来酰化壳聚糖（CS-MA）和硫醇衍生海藻酸钠（SA-SH）的简便，一锅法，制备了具有双重修复能力的新型原位可成型且具有原纤维增强的多糖基复合水凝胶。反应和离子相互作用。CS-MA与SA-SH的静电相互作用归因于作为增强填料的独特的原纤维网络。这款CS-MA / SA-SH复合水凝胶可在37°C下在12小时内通过动态二硫化物交换而自我修复裂缝，而无需任何外部干预。值得注意的是，通过引入钙离子，可以在1分钟内在水凝胶或多孔支架内实现快速愈合。此外，还可以通过以下方式获得可调形状双重交联，为优化更多生物医学应用的原纤维增强复合凝胶系统提供了优势。另外，细胞活力和增殖表明，用Ca ²⁺愈合之前和之后的两种凝胶都具有良好的细胞相容性。