Induced hypothermia in patients with septic shock and respiratory failure (CASS): a randomised, controlled, open-label trial.,The Lancet

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Induced hypothermia in patients with septic shock and respiratory failure (CASS): a randomised, controlled, open-label trial.
The Lancet ( IF 98.4 ) Pub Date : 2018-03-01 , DOI: 10.1016/s2213-2600(18)30004-3
Theis Skovsgaard Itenov ₁ , Maria Egede Johansen ₂ , Morten Bestle ₃ , Katrin Thormar ₄ , Lars Hein ₃ , Louise Gyldensted ₅ , Anne Lindhardt ₄ , Henrik Christensen ₆ , Stine Estrup ₇ , Henrik Planck Pedersen ₈ , Matthew Harmon ₉ , Uday Kant Soni ₁₀ , Silvia Perez-Protto ₁₁ , Nicolai Wesche ₃ , Ulrik Skram ₃ , John Asger Petersen ₄ , Thomas Mohr ₅ , Tina Waldau ₆ , Lone Musaeus Poulsen ₇ , Ditte Strange ₄ , Nicole P Juffermans ₉ , Daniel I Sessler ₁₂ , Else Tønnesen ₁₃ , Kirsten Møller ₁₄ , Dennis Karsten Kristensen ₂ , Alessandro Cozzi-Lepri ₁₅ , Jens D Lundgren ₂ , Jens-Ulrik Jensen ₁₆ ,

Affiliation

Department of Anesthesia and Intensive Care, Nordsjællands Hospital, Hillerød, Denmark; Centre of Excellence in Immunity and Infection/Centre of Excellence for Personalised Medicine of Infectious Complications in Immune Deficiency, Department of Infectious Diseases, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark.
Centre of Excellence in Immunity and Infection/Centre of Excellence for Personalised Medicine of Infectious Complications in Immune Deficiency, Department of Infectious Diseases, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark.
Department of Anesthesia and Intensive Care, Nordsjællands Hospital, Hillerød, Denmark.
Department of Anesthesia and Intensive Care, Bispebjerg Hospital, Copenhagen, Denmark.
Department of Anesthesia and Intensive Care, Herlev and Gentofte Hospital, Hellerup, Denmark.
Department of Anesthesia and Intensive Care, Herlev and Gentofte Hospital, Herlev, Denmark.
Department of Anesthesia and Intensive Care, Zealand University Hospital, Køge, Denmark.
Department of Anesthesia and Intensive Care, Roskilde Hospital, Roskilde, Denmark.
Department of Intensive Care, Academic Medical Center, Amsterdam, Netherlands.
Department of Anesthesia and Intensive Care, Horsens Hospital, Horsens, Denmark.
Center for Critical Care, Anesthesiology Institute, Cleveland Clinic, Cleveland, OH, USA; Department of Outcomes Research, Anesthesiology Institute, Cleveland Clinic, Cleveland, OH, USA.
Department of Outcomes Research, Anesthesiology Institute, Cleveland Clinic, Cleveland, OH, USA.
Department of Anesthesia and Intensive Care, Aarhus University Hospital, Aarhus, Denmark.
Department of Neuroanesthesiology, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark.
Centre for Clinical Research, Epidemiology, Modelling and Evaluation, Institute for Global Health, University College London, London, UK.
Centre of Excellence in Immunity and Infection/Centre of Excellence for Personalised Medicine of Infectious Complications in Immune Deficiency, Department of Infectious Diseases, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark; Respiratory Medicine Division, Department of Internal Medicine, Herlev and Gentofte Hospital, Hellerup, Denmark.

Animal models of serious infection suggest that 24 h of induced hypothermia improves circulatory and respiratory function and reduces mortality. We tested the hypothesis that a reduction of core temperature to 32-34°C attenuates organ dysfunction and reduces mortality in ventilator-dependent patients with septic shock.

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