Multifaceted Expression of Peptidergic Modulation in the Feeding System of Aplysia.,ACS Chemical Neuroscience

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Multifaceted Expression of Peptidergic Modulation in the Feeding System of Aplysia.
ACS Chemical Neuroscience ( IF 4.1 ) Pub Date : 2018-01-24 , DOI: 10.1021/acschemneuro.7b00447
Elizabeth C Cropper ₁ , Jian Jing _{1,

2} , Ferdinand S Vilim ₁ , Michael A Barry ₁ , Klaudiusz R Weiss ₁

Affiliation

Neuropeptides are present in species throughout the animal kingdom and generally exert actions that are distinct from those of small molecule transmitters. It has, therefore, been of interest to define the unique behavioral role of this class of substances. Progress in this regard has been made in experimentally advantageous invertebrate preparations. We focus on one such system, the feeding circuit in the mollusc Aplysia. We review research conducted over several decades that played an important role in establishing that peptide cotransmitters are released under behaviorally relevant conditions. We describe how this was accomplished. For example, we describe techniques developed to purify novel peptides, localize them to identified neurons, and detect endogenous peptide release. We also describe physiological experiments that demonstrated that peptides are bioactive under behaviorally relevant conditions. The feeding system is like others in that peptides exert effects that are both convergent and divergent. Work in the feeding system clearly illustrates how this creates potential for behavioral flexibility. Finally, we discuss experiments that determined physiological consequences of one of the hallmark features of peptidergic modulation, its persistence. Research in the feeding system demonstrated that this persistence can change network state and play an important role in determining network output.

中文翻译：

海兔摄食系统中肽能调节的多方面表达。

神经肽存在于整个动物界的物种中，通常发挥与小分子递质不同的作用。因此，定义此类物质的独特行为作用很有意义。在这方面已经在实验上有利的无脊椎动物制剂方面取得了进展。我们专注于一个这样的系统，即软体动物 Aplysia 中的进食回路。我们回顾了几十年来进行的研究，这些研究在确定肽共递质在行为相关条件下释放方面发挥了重要作用。我们描述了这是如何完成的。例如，我们描述了为纯化新肽、将它们定位到已识别的神经元以及检测内源性肽释放而开发的技术。我们还描述了证明肽在行为相关条件下具有生物活性的生理实验。喂养系统与其他系统一样，肽发挥的作用既会聚又会发散。在喂养系统中的工作清楚地说明了这如何创造行为灵活性的潜力。最后，我们讨论了确定肽能调节的标志性特征之一及其持久性的生理后果的实验。对馈送系统的研究表明，这种持久性可以改变网络状态，并在决定网络输出方面发挥重要作用。在喂养系统中的工作清楚地说明了这如何创造行为灵活性的潜力。最后，我们讨论了确定肽能调节的标志性特征之一及其持久性的生理后果的实验。对馈送系统的研究表明，这种持久性可以改变网络状态，并在决定网络输出方面发挥重要作用。在喂养系统中的工作清楚地说明了这如何创造行为灵活性的潜力。最后，我们讨论了确定肽能调节的标志性特征之一及其持久性的生理后果的实验。对馈送系统的研究表明，这种持久性可以改变网络状态，并在决定网络输出方面发挥重要作用。

更新日期：2018-01-08

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