During 2006–2016, hepatitis B virus (HBV) was detected in nearly 400 blood donors in the Netherlands and Flanders. Donor demographics and self-reported risk factors as disclosed during the donor exit interview were compared to HBV phylogenies of donor and reference sequences. First-time donors with chronic HBV-infection were often immigrants (67%) infected with genetically highly diverse strains of genotypes A (32%), B (8%), C (6%), D (53%) and E to H (1%). Each subtype was strongly associated with donor ethnicity. In contrast, 57/62 (93%) of acute/recent HBV infections occurred among indigenous donors, of whom 67% was infected with one specific widely circulating epidemic HBV-A2 lineage. HBV typing identified three distinct epidemiological profiles: the import of chronic HBV infections through migration, longstanding transmission of non-epidemic HBV-A2 strains within western-Europe, and the active transmission of one epidemic HBV-A2 strain most likely fueled by sexual risk behavior.

在2006–2016年期间，荷兰和法兰德斯的近400名献血者中发现了乙型肝炎病毒（HBV）。将在捐赠者出境采访期间披露的捐赠者人口统计资料和自我报告的危险因素与捐赠者序列和参考序列的HBV系统发育进行了比较。初次出现慢性HBV感染的捐献者通常是移民（67％），他们感染了遗传上高度多样化的基因型A型（32％），B型（8％），C型（6％），D型（53％）和E型。 H（1％）。每个亚型都与供体的种族密切相关。相反，在土著捐助者中发生了57/62（93％）急性/近期HBV感染，其中67％被一种特定的广泛传播的流行性HBV-A2谱系感染。HBV分型确定了三种截然不同的流行病学特征：通过迁徙输入慢性HBV感染，