Depression and anxiety have been considered to influence disease activity, and with great interest we read the recently published report by Michelsen et al .1 In this large, prospective, multicentre observational study, depression and anxiety reduced the likelihood of joint remission based on composite scores, in rheumatoid arthritis (RA) after 3 and 6 months. Differences were predominantly caused by subjective markers of disease activity rather than by C reactive protein or erythrocyte sedimentation rate. The study cannot prove causality; however, their findings imply that baseline depression/anxiety can impair the fulfilment of remission criteria during follow-up, influencing important treatment decisions. As replication is a keystone in research, we aimed to validate their findings in an independent cohort, the Leiden Early Arthritis Clinic (EAC), to assess generalisability of the results. The EAC is a population-based inception cohort of patients with newly diagnosed arthritis that started in 1993; from 2010 onwards patients completed the Short Form-36 (SF-36) at …

中文翻译：

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抑郁和焦虑与类风湿性关节炎 1 年后缓解较少有关

抑郁和焦虑被认为会影响疾病活动，我们饶有兴趣地阅读了 Michelsen 等人最近发表的报告。1 在这项大型、前瞻性、多中心观察性研究中，基于综合评分，抑郁和焦虑降低了关节缓解的可能性, 在 3 和 6 个月后的类风湿性关节炎 (RA)。差异主要是由疾病活动的主观标志物引起的，而不是由 C 反应蛋白或红细胞沉降率引起的。该研究无法证明因果关系；然而，他们的发现意味着基线抑郁/焦虑会影响随访期间缓解标准的实现，影响重要的治疗决策。由于复制是研究的基石，我们的目标是在一个独立的队列中验证他们的发现，莱顿早期关节炎诊所 (EAC)，以评估结果的普遍性。EAC 是 1993 年开始的以人群为基础的新诊断关节炎患者队列；从 2010 年起，患者在……完成了 Short Form-36 (SF-36)