We read the report by Zen et al 1 on the impact of lupus low disease activity state (LLDAS) on damage accrual with great interest and would like to congratulate the authors on their work. In this single-centre Caucasian cohort, followed for 7 years, only 38 of their 293 patients (11.3%) failed to achieve LLDAS for at least 1 year; moreover, of the 255 patients who achieved LLDAS for at least 1 year, 246 (96.5%) also satisfied the definition of remission for the same length of time. And, in 214 (83.9%) patients, the duration of remission was the same as that of LLDAS. Being in LLDAS for at least 2 years was associated with a reduced risk of damage; …

中文翻译：

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系统性红斑狼疮以缓解或低疾病活动度为目标

我们非常感兴趣地阅读了 Zen 等人 1 关于狼疮低疾病活动状态 (LLDAS) 对损伤累积的影响的报告，并祝贺作者的工作。在这个单中心的白人队列中，随访了 7 年，他们的 293 名患者中只有 38 名（11.3%）至少 1 年未能达到 LLDAS；此外，在获得 LLDAS 至少 1 年的 255 名患者中，246 名（96.5%）也满足相同时间长度的缓解定义。并且，在 214 名（83.9%）患者中，缓解持续时间与 LLDAS 相同。使用 LLDAS 至少 2 年与降低损坏风险有关；…