Liver diseases are one of the leading causes of death in the world. In spite of tremendous advances in modern drug research, effective and safe hepatoprotective agents are still in urgent demand. Natural products are undoubtedly valuable sources for drug leads. A number of natural triterpenoids were reported to possess pronounced hepatoprotective effects, and triterpenoids have become one of the most important classes of natural products for hepatoprotective agents. However, the significance of natural triterpenoids has been underestimated in the hepatoprotective drug discovery, with only very limited triterpenoids being covered in the reviews of hepatoprotective natural products. In this paper, ca 350 natural triterpenoids with reported hepatoprotective effects in ca 120 references between 1975 and 2016 will be reviewed, and the structure-activity relationships of certain types of natural triterpenoids, if available, will be discussed. Patents are not included.

肝病是世界上主要的死亡原因之一。尽管现代药物研究取得了巨大进步，但仍然迫切需要有效和安全的肝保护剂。天然产物无疑是毒品线索的宝贵来源。据报道，许多天然三萜类化合物具有显着的肝保护作用，并且三萜类化合物已成为用于肝保护剂的最重要的天然产物类别之一。但是，天然三萜类化合物的重要性在保肝药物的发现中被低估了，在保肝性天然产物的评论中仅涵盖了非常有限的三萜类化合物。在本文中，CA 350个在报道保肝效果的天然三萜类化合物CA将审查1975年至2016年之间的120篇参考文献，并讨论某些类型的天然三萜类化合物（如果有）的构效关系。不包括专利。