A short synthesis of an enantiopure pyrrolobenzodiazepine (PBD) dilactam featuring early installation of the C2-C3 unsaturation is reported. An enantioselective cooperative catalytic cascade followed by self-disproportionation of enantiomers via sublimation afforded the enantiopure 2,3-dihydro-1H-pyrrole key intermediate, 1. N-Acylation followed by reduction and lactam formation furnished the PBD dilactam.

中文翻译：

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通过对映异构体的自歧化作用获得对映纯的吡咯并苯并二氮杂（PBD）双内酰胺核

据报道，对映体纯的吡咯并苯并二氮杂（PBD）地内酰胺的合成很短，其特征是早期安装了C2-C3不饱和键。对映选择性协同催化级联反应，然后通过升华使对映异构体自歧化，得到对映纯2，3-二氢-1 H-吡咯关键中间体，1。N-酰化，然后还原和形成内酰胺，提供了PBD地内酰胺。