Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are ubiquitous municipal wastewater pollutants of which several are resistant to degradation in conventional wastewater treatment, and represent a major environmental health concern worldwide. An alternative treatment, the bio-electro-Fenton process, has received increasing attention in past years. In this process the strong oxidant HO is formed using the electrons derived from bacterial oxidation of organic substrate. In this work, a laboratory scale microbial electrolysis cell based bio-electro-Fenton process was developed for the treatment of four different NSAIDs. The system was demonstrated to remove low concentration NSAIDs from water and wastewater and all tested parameters (cathode pH, cathode air-flow, cathode Fe²⁺ concentration, applied voltage, NSAIDs concentration and reaction time) were found to affect the apparent first order rate constant and removal efficiency for NSAIDs. Optimum parameter values were found to be pH = 2, Fe⁺² = 7.5 mM, air-flow = 8 mL min⁻¹, applied voltage = 0.3 V; the apparent rate constant was higher for higher NSAIDs initial concentration. For reaction times of 5 h removal efficiencies were 59–61% for Ketoprofen, 87–97% for Diclofenac, 80–86% for Ibuprofen and 75–81% for Naproxen. Prolonged reaction times lead to substantial increase in removal efficiencies for Ketoprofen and Naproxen. Finally results obtained with real wastewater show lower removal rate constants than with distilled water matrices suggesting interference from wastewater components in the NSAIDs oxidation process. The results offer insight into future developments of an efficient platform for wastewater treatment technology targeting micropollutants.

非甾体类抗炎药（NSAIDs）是普遍存在的市政废水污染物，其中的几种对常规废水处理中的降解具有抗性，并且代表着全球范围内对环境健康的主要关注。近年来，生物电芬顿法是一种替代治疗方法，受到越来越多的关注。在此过程中，使用源自有机底物细菌氧化的电子形成强氧化剂HO。在这项工作中，开发了一种基于实验室规模的微生物电解池的生物电芬顿法，用于治疗四种不同的非甾体抗炎药。该系统已被证明可去除水和废水中的低浓度NSAID，以及所有测试参数（阴极pH，阴极气流，阴极Fe ²⁺浓度，施加电压，非甾体抗炎药的浓度和反应时间被发现会影响非甾体抗炎药的表观一级速率常数和去除效率。发现最佳参数值为pH = 2，Fe ⁺²  = 7.5 mM，空气流量= 8 mL min ^-1，施加电压= 0.3 V；对于较高的NSAIDs初始浓度，表观速率常数较高。对于5小时的反应时间，酮洛芬的去除效率为59–61％，双氯芬酸为87–97％，布洛芬为80–86％，萘普生为75–81％。延长的反应时间导致酮洛芬和萘普生的去除效率大大提高。最后，用真实废水获得的结果显示出比蒸馏水基质更低的去除速率常数，这表明在NSAIDs氧化过程中废水成分的干扰。结果提供了对针对微污染物的废水处理技术高效平台的未来发展的见识。