Polysaccharide‐Based Controlled Release Systems for Therapeutics Delivery and Tissue Engineering: From Bench to Bedside,Advanced Science

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Polysaccharide‐Based Controlled Release Systems for Therapeutics Delivery and Tissue Engineering: From Bench to Bedside
Advanced Science ( IF 14.3 ) Pub Date : 2018-01-08 , DOI: 10.1002/advs.201700513
Tianxin Miao _{1,

2} , Junqing Wang _{1,

3} , Yun Zeng ₄ , Gang Liu _{1,

5,

6} , Xiaoyuan Chen ₇

Affiliation

Polysaccharides or polymeric carbohydrate molecules are long chains of monosaccharides that are linked by glycosidic bonds. The naturally based structural materials are widely applied in biomedical applications. This article covers four different types of polysaccharides (i.e., alginate, chitosan, hyaluronic acid, and dextran) and emphasizes their chemical modification, preparation approaches, preclinical studies, and clinical translations. Different cargo fabrication techniques are also presented in the third section. Recent progresses in preclinical applications are then discussed, including tissue engineering and treatment of diseases in both therapeutic and monitoring aspects. Finally, clinical translational studies with ongoing clinical trials are summarized and reviewed. The promise of new development in nanotechnology and polysaccharide chemistry helps clinical translation of polysaccharide‐based drug delivery systems.

中文翻译：

用于治疗递送和组织工程的多糖控释系统：从实验室到临床

多糖或聚合碳水化合物分子是通过糖苷键连接的长链单糖。天然结构材料广泛应用于生物医学领域。本文涵盖了四种不同类型的多糖（即海藻酸盐、壳聚糖、透明质酸和葡聚糖），并重点介绍了它们的化学修饰、制备方法、临床前研究和临床转化。第三部分还介绍了不同的货物制造技术。然后讨论了临床前应用的最新进展，包括组织工程和疾病治疗和监测方面的治疗。最后，对正在进行的临床试验的临床转化研究进行了总结和回顾。纳米技术和多糖化学的新发展有望有助于基于多糖的药物输送系统的临床转化。

更新日期：2018-01-08

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