Nature Reviews Genetics ( IF 39.1 ) Pub Date : 2018-01-08 , DOI: 10.1038/nrg.2017.104 Robert Plomin 1 , Sophie von Stumm 2
Intelligence — the ability to learn, reason and solve problems — is at the forefront of behavioural genetic research. Intelligence is highly heritable and predicts important educational, occupational and health outcomes better than any other trait. Recent genome-wide association studies have successfully identified inherited genome sequence differences that account for 20% of the 50% heritability of intelligence. These findings open new avenues for research into the causes and consequences of intelligence using genome-wide polygenic scores that aggregate the effects of thousands of genetic variants.
中文翻译:
新的智力遗传学
智力——学习、推理和解决问题的能力——处于行为遗传学研究的前沿。智力具有高度遗传性,比任何其他特征都能更好地预测重要的教育、职业和健康结果。最近的全基因组关联研究已成功识别出遗传基因组序列差异,这些差异占 50% 智力遗传力的 20%。这些发现为利用全基因组多基因评分来研究智力的原因和后果开辟了新的途径,这些评分汇总了数千种遗传变异的影响。