Conducting polymer poly(3,4-ethylenedioxythiophene) (PEDOT) possesses high electrical conductivity but limited catalytic activity, and doping with suitable nanomaterial to fabricate multifunctional electrical substrate is an ideal approach to broaden the application of PEDOT. Herein, [email protected] (AG) core-shell nanoparticles with high conductivity, catalytic activity and stability, were synthesized and doped into PEDOT to build PEDOT/AG nanocomposite material by a facile electrodeposition method. The PEDOT/AG composite exhibited high conductivity and excellent catalytic activity toward the redox of paracetamol, and owing to the presence of AG nanoparticles, the electrochemical signals and peak profiles of paracetamol at the PEDOT/AG modified electrode were significantly improved. Under optimum conditions, the PEDOT/AG modified electrode exhibited high sensitivity to paracetamol over a wide linear range of concentrations from 0.15 μM to 5.88 mM, with a detection limit of 41 nM (S/N = 3). Furthermore, the fabricated sensor exhibited high selectivity and long-term stability, and was capable of detecting paracetamol in real pharmaceutical samples with satisfying accuracy.

导电聚合物聚（3,4-乙撑二氧噻吩）（PEDOT）具有较高的电导率，但催化活性有限，掺杂合适的纳米材料来制备多功能电基底是扩大PEDOT应用的理想方法。本文中，合成了具有高电导率，催化活性和稳定性的[电子邮件保护]（AG）核壳纳米粒子，并通过简便的电沉积方法将其掺入PEDOT中以构建PEDOT / AG纳米复合材料。PEDOT / AG复合材料表现出高电导率和优异的对乙酰氨基酚的氧化还原催化活性，由于存在AG纳米粒子，PEDOT / AG修饰电极上对乙酰氨基酚的电化学信号和峰形得到了显着改善。在最佳条件下，PEDOT / AG修饰电极在0.15μM至5.88 mM的宽浓度范围内对扑热息痛表现出高灵敏度，检出限为41 nM（S / N = 3）。此外，所制造的传感器表现出高选择性和长期稳定性，并且能够以令人满意的精度检测实际药物样品中的扑热息痛。