In this issue of Cancer Cell, Yaeger et al. report mutations, copy number variations, and selected rearrangements from a large series of metastatic colorectal carcinomas and primaries that produced metastases. The results provide important insights into differences in anatomical site of origin, age at onset, etiologic factors, and therapeutic responses.

中文翻译：

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表征杀手性结肠直肠癌。

在本期《癌细胞》中，Yaeger等人。报告了一系列转移性结直肠癌和产生转移的原发癌的突变，拷贝数变异和选定的重排。结果为深入了解起源的解剖部位，发病年龄，病因和治疗反应提供了重要的见识。