Differentiation features in cancer cells are typically attributed to the cell of origin. In this issue of Cancer Cell, Drummond et al. demonstrate a transdifferentiation program apparent in rhabdomyosarcomas (cancers with skeletal muscle differentiation features) arising through cell fate reprogramming from a single oncogene activation in endothelial cell precursors.

中文翻译：

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名字叫什么？肉瘤发生中的细胞命运重编程。

癌细胞中的分化特征通常归因于起源细胞。在本期《癌细胞》中，Drummond等人。证明了在横纹肌肉瘤（具有骨骼肌分化特征的癌症）中出现的转分化程序是由内皮细胞前体中单个癌基因激活引起的细胞命运重编程引起的。