2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is an environmental contaminant and its toxicity is mediated by the aryl hydrocarbon receptor (AHR). Mechanisms of TCDD cardiovascular toxicity consist of oxidative stress, growth factor modulation, and ionic current alteration. It is indicated that the rodent cardiovascular system is a target for TCDD cardiomyopathy. Here, our understanding of TCDD cardiovascular toxicity is reviewed.

中文翻译：

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2,3,7,8-四氯二苯并-对二恶英诱导的心血管毒性的机制：概述

2,3,7,8-四氯二苯并-对二恶英（TCDD）是一种环境污染物，其毒性由芳烃受体（AHR）介导。TCDD心血管毒性的机制包括氧化应激，生长因子调节和离子电流改变。表明啮齿动物心血管系统是TCDD心肌病的靶标。在这里，我们对TCDD心血管毒性的理解进行了综述。