A palladium/norbornene-catalyzed ortho acylation for the efficient synthesis of functionalized alkyl aryl ketones is reported. Studies on the electronic and steric properties of mixed aryl anhydrides indicated that the cross-coupling favored with the electron-enriched aryl acyl group. DFT calculation on the oxidative addition of Pd(II) with 2,4,6-(Cl)₃C₆H₂CO₂C(O)Ph suggested that 2,4,6-(Cl)₃C₆H₂C(O)–O bond cleavage was more kinetically disfavored than that of the PhC(O)–O bond by 11.7 kJ/mol.

中文翻译：

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钯/降冰片烯催化的混合脂肪族邻位脂肪酰化反应：选择性和反应性

报道了钯/降冰片烯催化的邻位酰化，用于有效合成官能化的烷基芳基酮。对混合的芳基酸酐的电子和空间特性的研究表明，交叉偶联有利于富电子的芳基酰基。用2,4,6-（Cl）₃ C ₆ H ₂ CO ₂ C（O）Ph氧化Pd（II）的DFT计算表明2,4,6-（Cl）₃ C ₆ H ₂ C （O）–O键的断裂在动力学上比PhC（O）–O键的断裂更不利于11.7 kJ / mol。