Background

Previous studies have found an increased risk for invasive cutaneous melanoma (CM) among those with a history of keratinocyte carcinoma (KC).

Objective

The aim of this study was to evaluate the risk of CM death after KC.

Methods

The study was based on the Health Professionals Follow-up Study. A Cox proportional hazards model was used to examine the hazard ratio (HR) of death due to CM associated with personal history of KC among the entire study population (primary analysis) and among participants with invasive CM (secondary analysis), respectively.

Results

We documented a total of 908 participants with invasive CM over a total of 0.7 million person-years of follow-up. Among all participants, the risk for development of either lethal or nonlethal invasive CM increased for those with a history of KC. The risk for death due to melanoma based on KC history was not significantly increased, with an HR of 1.53 (95% confidence interval, 0.95-2.46). In the case-only analysis, those with a history of KC had a significantly lower risk for death due to melanoma than those with no such history (HR, 0.60; 95% confidence interval, 0.35-0.94).

Limitations

Because the population covered by the Health Professionals Follow-up Study consists exclusively of male health professionals, the results of this study may not be extended to the entire population.

Conclusion

Personal history of KC is associated with a decreased risk for melanoma-specific death among male patients with invasive CM.

中文翻译：

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角质形成细胞癌的个人病史与男性侵袭性黑色素瘤死亡风险降低相关

 背景

先前的研究发现，有角化细胞癌（KC）病史的人患侵袭性皮肤黑色素瘤（CM）的风险增加。

 客观的

本研究的目的是评估 KC 后 CM 死亡的风险。

 方法

该研究基于卫生专业人员随访研究。使用 Cox 比例风险模型分别检查整个研究人群（主要分析）和侵袭性 CM 参与者（二次分析）中与 KC 个人病史相关的 CM 死亡风险比 (HR)。

 结果

我们在总计 70 万人年的随访中记录了总共 908 名患有侵入性 CM 的参与者。在所有参与者中，有 KC 病史的参与者发生致死性或非致死性侵袭性 CM 的风险增加。基于 KC 病史的黑色素瘤死亡风险并未显着增加，HR 为 1.53（95% 置信区间，0.95-2.46）。在仅病例分析中，有 KC 病史的患者因黑色素瘤死亡的风险显着低于无 KC 病史的患者（HR，0.60；95% 置信区间，0.35-0.94）。

 局限性

由于卫生专业人员随访研究覆盖的人群完全由男性卫生专业人员组成，因此本研究的结果可能不会扩展到整个人群。

 结论

KC 个人病史与侵袭性 CM 男性患者黑色素瘤特异性死亡风险降低相关。