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Accessing substituted pyrrolidines via formal [3+2] cycloaddition of 1,3,5-triazinanes and donor-acceptor cyclopropanes
Tetrahedron Letters ( IF 1.5 ) Pub Date : 2018-01-06 , DOI: 10.1016/j.tetlet.2018.01.016
Zhi-Yao Chu , Na Li , Dan Liang , Zheng-Hui Li , Yong-Sheng Zheng , Ji-Kai Liu

The formal [3+2] cycloaddition of 1,3,5-triaryl-1,3,5-triazinanes with donor-acceptor cyclopropanes has been found to provide pyrrolidines in good to excellent yields under mild reaction conditions. Preliminary mechanistic investigation indicates that this formal [3+2] cycloaddition reaction proceeds through competing SN1 and SN2 pathways.



中文翻译:

通过1,3,5-三嗪并有供体-受体环丙烷的[3 + 2]环加成反应获得取代的吡咯烷

已经发现,在温和的反应条件下,将1,3,5-三芳基-1,3,5-三嗪酮与供体-受体环丙烷进行正式的[3 + 2]环加成反应可提供吡咯烷类化合物。初步的机理研究表明,这种正式的[3 + 2]环加成反应是通过竞争性的S N 1和S N 2途径进行的。

更新日期:2018-01-06
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