A highly efficient gram-scale method for the C(4)-functionalization of sydnone imine hydrochloride derivatives was developed. This new approach was realized through consecutive reactions including the preparation of a C(3)-substituted N₆-tert-butoxycarbonyl sydnone imine derivative, deprotonation with n-BuLi and reaction of the lithiated-intermediate with an electrophilic agent, and removal of the Boc protecting group.

中文翻译：

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Ñ ₆ -叔斯德酮亚胺的丁氧羰基衍生物的制备和使用合成

开发了一种高效的克级方法，用于对亚砜亚胺盐酸盐衍生物进行C（4）-官能化。这种新方法是通过连续的反应，包括一个C（3）的制备实现取代Ñ ₆ -叔丁氧羰基斯德酮亚胺衍生物，脱质子化以Ñ正丁基锂，并用亲电试剂的锂化中间体的反应，并除去的Boc保护基团。