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N6-tert-Butoxycarbonyl derivatives of sydnone imines: Preparation and synthetic use
Tetrahedron Letters ( IF 1.5 ) Pub Date : 2018-01-06 , DOI: 10.1016/j.tetlet.2018.01.019
Ilya A. Cherepanov , Alina S. Samarskaya , Ivan A. Godovikov , Konstantin A. Lyssenko , Anastasia A. Pankratova , Valery N. Kalinin

A highly efficient gram-scale method for the C(4)-functionalization of sydnone imine hydrochloride derivatives was developed. This new approach was realized through consecutive reactions including the preparation of a C(3)-substituted N6-tert-butoxycarbonyl sydnone imine derivative, deprotonation with n-BuLi and reaction of the lithiated-intermediate with an electrophilic agent, and removal of the Boc protecting group.



中文翻译:

Ñ 6 -斯德酮亚胺的丁氧羰基衍生物的制备和使用合成

开发了一种高效的克级方法,用于对亚砜亚胺盐酸盐衍生物进行C(4)-官能化。这种新方法是通过连续的反应,包括一个C(3)的制备实现取代Ñ 6 -丁氧羰基斯德酮亚胺衍生物,脱质子化以Ñ正丁基锂,并用亲电试剂的锂化中间体的反应,并除去的Boc保护基团。

更新日期:2018-01-06
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