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Ir-catalyzed asymmetric hydrogenation of simple ketones with chiral ferrocenyl P,N,N-ligands
Tetrahedron Letters ( IF 1.5 ) Pub Date : 2018-01-06 , DOI: 10.1016/j.tetlet.2018.01.020
Chao Qin , Chuan-Jin Hou , Hongzhu Liu , Yan-Jun Liu , De-Zhi Huang , Xiang-Ping Hu

The Ir-catalyzed asymmetric hydrogenation of simple aromatic ketones with chiral ferrocenyl P,N,N-ligands has been developed. Under the optimized conditions, a wide range of ketones were hydrogenated to afford the corresponding chiral alcohols in good to excellent enantioselectivities (up to 98% ee).



中文翻译:

Ir手性二茂铁二茂铁P,N,N配体对酮的不对称催化加氢

已开发了具有手性二茂铁基P,N,N-配体的简单芳族酮的Ir催化不对称加氢反应。在优化的条件下,将广泛的酮氢化,得到相应的手性醇,对映体的对映选择性好至极佳(ee高达98%)。

更新日期:2018-01-06
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