In Aqua Veritas: The Indispensable yet Mostly Ignored Role of Water in Phase Separation and Membrane-less Organelles,Biochemistry

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In Aqua Veritas: The Indispensable yet Mostly Ignored Role of Water in Phase Separation and Membrane-less Organelles
Biochemistry ( IF 2.9 ) Pub Date : 2018-01-05 00:00:00 , DOI: 10.1021/acs.biochem.7b01215
Boris Y. Zaslavsky ₁ , Vladimir N. Uversky _{2,

3}

Affiliation

Despite the common practice of presenting structures of biological molecules on an empty background and the assumption that interactions between biological macromolecules take place within the inert solvent, water represents an active component of various biological processes. This Perspective addresses indispensable, yet mostly ignored, roles of water in biological liquid–liquid phase transitions and in the biogenesis of various proteinaceous membrane-less organelles. We point out that changes in the structure of water reflected in the changes in its abilities to donate and/or accept hydrogen bonds and participate in dipole–dipole and dipole–induced dipole interactions in the presence of various solutes (ranging from small molecules to synthetic polymers and biological macromolecules) might represent a driving force for the liquid–liquid phase separation, define partitioning of various solutes in formed phases, and define the exceptional ability of intrinsically disordered proteins to be engaged in the formation of proteinaceous membrane-less organelles.

中文翻译：

在Aqua Veritas中：水在相分离和无膜细胞器中不可或缺的作用

尽管在空的背景下呈现生物分子结构的常规做法以及假设生物大分子之间的相互作用发生在惰性溶剂中的假设，但是水仍是各种生物过程的活性成分。该观点探讨了水在生物液-液相转变以及各种无蛋白质膜无细胞器的生物发生中不可或缺但几乎被忽略的作用。

更新日期：2018-01-05

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