Simultaneous PET-MRI Confirms That Cerebral Blood Flow Does Not Confound PET Neuroreceptor Activation Studies,ACS Chemical Neuroscience

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Simultaneous PET-MRI Confirms That Cerebral Blood Flow Does Not Confound PET Neuroreceptor Activation Studies
ACS Chemical Neuroscience ( IF 4.1 ) Pub Date : 2018-01-05 00:00:00 , DOI: 10.1021/acschemneuro.7b00489
Lauri Nummenmaa _{1,

2} , Lauri Tuominen ₃ , Jussi Hirvonen _{1,

4}

Affiliation

Positron emission tomography (PET) and endogenous competition paradigms are widely used for studying neuroreceptor activation in humans in vivo. Changes in cerebral blood triggered by the experimentation, such as amphetamine administration, could influence both tracer delivery and washout, thus biasing the results. A recent study tested this assumption in baboons by measuring radiotracer binding with PET while measuring simultaneously cerebral blood flow with arterial spin labeled functional magnetic resonance imaging. Cerebral blood flow was modulated by CO₂ inhalation. Hypercapnia led to substantial alterations in blood flow with no detectable alteration in binding of the reversibly binding radiotracers [¹¹C]raclopride and [¹⁸F]fallypride. These results rule out a serious confound for the endogenous competition paradigm, and demonstrate the importance of simultaneous PET and MRI measurements when studying brain function.

中文翻译：

同时进行PET-MRI证实脑血流不会混淆PET神经受体激活研究

正电子发射断层扫描（PET）和内源性竞争范例已广泛用于研究人体中神经受体的激活。实验触发的脑部血液变化（例如安非他明给药）可能会影响示踪剂的输送和清除，从而使结果产生偏差。一项最新研究在狒狒中通过测量放射性示踪剂与PET的结合力，同时通过动脉自旋标记的功能磁共振成像测量脑血流量，测试了这一假设。通过吸入CO ₂调节脑血流量。高碳酸血症导致血流的实质性改变，而可逆结合的放射性示踪剂[ ¹¹ C]雷氯必利和[ ¹⁸F] falpride。这些结果排除了内源性竞争范式的严重困惑，并证明了在研究脑功能时同时进行PET和MRI测量的重要性。

更新日期：2018-01-05

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