Light therapy has become the subject of research on cancer treatment because of its selectivity, low invasive damage, and side effects. Photothermal therapy (PTT) and photodynamic therapy (PDT) are prevalent treatments used to induce cancer cell apoptosis by generating heat and reactive oxygen species (ROS). In this study, mesoporous silica shell-coated gold nanorods ([email protected]) are synthesized by seed crystal growth method. [email protected] are assembled into nanocomposites through electrostatic adsorption with lanthanide-doped upconversion nanoparticles (UCNP). When controlling the aspect ratio of gold nanorods (AuNRs), the surface plasmon resonance peaks of the short-axis and the long-axis match the maximum absorption cross section at 520 and 660 nm of the fluorescence light released by the UCNPs. The converted fluorescence stimulates AuNRs to generate heat through energy transfer. ROS production is induced by loading the photosensitizer Merocyanine 540 (MC540) in the mesoporous silica layer and is further enhanced through the surface plasma resonance effect of the AuNRs. This novel nanoplatform combines PTT and PDT in a single 808 nm near-infrared synergistic light therapy.

中文翻译：

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使用金纳米棒混合上转换粒子的包含光热和光动力疗法的单808 nm激光治疗

由于光疗法的选择性，低侵害性和副作用，光疗法已成为癌症治疗的研究主题。光热疗法（PTT）和光动力疗法（PDT）是用于通过产生热量和活性氧（ROS）诱导癌细胞凋亡的流行疗法。在这项研究中，通过籽晶生长方法合成了介孔二氧化硅壳包被的金纳米棒（[受电子邮件保护]）。[受电子邮件保护]通过镧系元素掺杂的上转换纳米粒子（UCNP）的静电吸附组装成纳米复合材料。当控制金纳米棒（AuNRs）的长宽比时，短轴和长轴的表面等离振子共振峰与UCNPs释放的荧光在520和660 nm处的最大吸收截面相匹配。转换后的荧光刺激AuNRs通过能量转移产生热量。通过将光敏剂花菁540（MC540）负载在介孔二氧化硅层中诱导产生ROS，并通过AuNRs的表面等离子体共振效应进一步提高ROS的产生。这种新颖的纳米平台在单个808 nm近红外协同光疗法中结合了PTT和PDT。