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Co(iii)-Catalyzed N-chloroamide-directed C–H activation for 3,4-dihydroisoquinolone synthesis†
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2018-01-05 00:00:00 , DOI: 10.1039/c7qo01124e
Xiaolong Yu 1, 2, 3, 4, 5 , Kehao Chen 1, 2, 3, 4, 5 , Qi Wang 1, 2, 3, 4, 5 , Wenjing Zhang 1, 2, 3, 4, 5 , Jin Zhu 1, 2, 3, 4, 5
Affiliation  

The synthesis of 3,4-dihydroisoquinolone via Co(III)-catalyzed C–H activation has been achieved for the first time. N-Chloroamides as a C–H activation directing synthon react effectively with alkenes at room temperature, enabling the incorporation of diverse reactive functionalities and substitution patterns into the target heterocycles.

中文翻译:

Co(iii)催化的N-酰胺定向的C–H活化,用于3,4-二氢异喹诺酮的合成

通过Co(III)催化的C–H活化合成3,4-二氢异喹诺酮是第一次。N-酰胺作为C–H激活的引导合成子,在室温下可与烯烃有效反应,从而将各种反应性官能团和取代模式纳入目标杂环中。
更新日期:2018-01-05
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