Dual chain extension effect and antibacterial properties of biomolecules interleaved within LDH dispersed into PBS by in situ polymerization†,Dalton Transactions

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Dual chain extension effect and antibacterial properties of biomolecules interleaved within LDH dispersed into PBS by in situ polymerization†
Dalton Transactions ( IF 3.5 ) Pub Date : 2018-01-05 00:00:00 , DOI: 10.1039/c7dt03914j
Grazia Totaro _{1,

2,

3,

4,

5} , Laura Sisti _{1,

2,

3,

4,

5} , Annamaria Celli _{1,

2,

3,

4,

5} , Irene Aloisio _{4,

6,

7,

8} , Diana Di Gioia _{4,

6,

7,

8} , Adam A. Marek _{9,

10,

11,

12,

13} , Vincent Verney _{9,

10,

11} , Fabrice Leroux _{9,

10,

11}

Affiliation

Nanocomposites based on poly(butylene succinate) (PBS) and hydrotalcite-type anionic clays (HTs) organo-modified with biomolecules characterized by antibacterial and/or antioxidant activities, such as L-ascorbic acid (ASA), phloretic acid (HPP), L-tyrosine (TYR) and L-tryptophan (TRP), have been prepared by in situ polymerization. From XRD analysis and rheology experiments in a molten polymer state, intercalated HT hybrid platelets acting here as a hybrid filler are found to be well dispersed into polymers while providing a chain extension effect on PBS. Moreover, the molecules, when hosted within a HT interlayer gap, do preserve their pristine antibacterial activity, both in HT and in the resulting PBS composites. In particular, under the experimental conditions tested, HT/ASA and HT/TYR present the best combination of both properties (chain extension effect and antibacterial), especially versus E. coli as high as 90 and 97% of inhibition, respectively, using 2.5 wt% hybrid filler only. These findings open future applications for PBS associated with the hybrid HT filler as multifunctional materials in active packaging applications.

中文翻译：

通过原位聚合分散在PBS中的LDH内交错的生物分子的双链延伸效应和抗菌特性†

基于聚（丁二酸丁二酯）（PBS）和水滑石型阴离子粘土（HTs）的纳米复合材料，该纳米复合材料已被生物分子改性，其特征在于具有抗菌和/或抗氧化活性，例如L-抗坏血酸（ASA），发磷酸（HPP），L-酪氨酸（TYR）和L-色氨酸（TRP）已通过原位制备聚合。通过在熔融聚合物状态下的XRD分析和流变学实验，发现在这里充当杂化填料的插层HT杂化血小板可以很好地分散到聚合物中，同时对PBS提供扩链作用。此外，这些分子在HT夹层间隙内存在时，在HT和所得的PBS复合材料中均确实保留了其原始的抗菌活性。特别是，在测试的实验条件下，HT / ASA和HT / TYR表现出两种特性（扩链效果和抗菌性）的最佳组合，尤其是与大肠杆菌相比仅使用2.5 wt％的杂化填料，抑制率分别高达90％和97％。这些发现为混合HT填料相关的PBS作为多功能包装材料在主动包装中的应用打开了未来的应用。

更新日期：2018-01-05

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