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Joint associations of a polygenic risk score and environmental risk factors for breast cancer in the Breast Cancer Association Consortium
International Journal of Epidemiology ( IF 6.4 ) Pub Date : 2018-01-05 , DOI: 10.1093/ije/dyx242
Anja Rudolph 1, 2 , Minsun Song 3 , Mark N Brook 4 , Roger L Milne 5, 6 , Nasim Mavaddat 7 , Kyriaki Michailidou 7, 8 , Manjeet K Bolla 7 , Qin Wang 7 , Joe Dennis 7 , Amber N Wilcox 9 , John L Hopper 6 , Melissa C Southey 10 , Renske Keeman 11 , Peter A Fasching 12, 13 , Matthias W Beckmann 12 , Manuela Gago-Dominguez 14, 15 , Jose E Castelao 16 , Pascal Guénel 17 , Thérèse Truong 17 , Stig E Bojesen 18, 19, 20 , Henrik Flyger 21 , Hermann Brenner 22, 23, 24 , Volker Arndt 22 , Hiltrud Brauch 24, 25, 26 , Thomas Brüning 27 , Arto Mannermaa 28, 29, 30 , Veli-Matti Kosma 28, 29, 30 , Diether Lambrechts 31, 32 , Machteld Keupers 33 , Fergus J Couch 34 , Celine Vachon 35 , Graham G Giles 5, 6 , Robert J MacInnis 5, 6 , Jonine Figueroa 9, 36 , Louise Brinton 9 , Kamila Czene 37 , Judith S Brand 37 , Marike Gabrielson 37 , Keith Humphreys 37 , Angela Cox 38 , Simon S Cross 39 , Alison M Dunning 40 , Nick Orr 41 , Anthony Swerdlow 4, 41 , Per Hall 37 , Paul D P Pharoah 7, 40 , Marjanka K Schmidt 11, 42 , Douglas F Easton 7, 40 , Nilanjan Chatterjee 9, 43, 44 , Jenny Chang-Claude 1, 45 , Montserrat García-Closas 9
Affiliation  

Polygenic risk scores (PRS) for breast cancer can be used to stratify the population into groups at substantially different levels of risk. Combining PRS and environmental risk factors will improve risk prediction; however, integrating PRS into risk prediction models requires evaluation of their joint association with known environmental risk factors.

中文翻译:


乳腺癌协会联盟中乳腺癌多基因风险评分与环境风险因素的联合关联



乳腺癌的多基因风险评分 (PRS) 可用于将人群分为风险水平显着不同的组。结合PRS和环境风险因素将提高风险预测;然而,将 PRS 纳入风险预测模型需要评估它们与已知环境风险因素的联合关联。
更新日期:2018-05-06
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