Joint associations of a polygenic risk score and environmental risk factors for breast cancer in the Breast Cancer Association Consortium,International Journal of Epidemiology

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Joint associations of a polygenic risk score and environmental risk factors for breast cancer in the Breast Cancer Association Consortium
International Journal of Epidemiology ( IF 6.4 ) Pub Date : 2018-01-05 , DOI: 10.1093/ije/dyx242
Anja Rudolph _{1,

2} , Minsun Song ₃ , Mark N Brook ₄ , Roger L Milne _{5,

6} , Nasim Mavaddat ₇ , Kyriaki Michailidou _{7,

8} , Manjeet K Bolla ₇ , Qin Wang ₇ , Joe Dennis ₇ , Amber N Wilcox ₉ , John L Hopper ₆ , Melissa C Southey ₁₀ , Renske Keeman ₁₁ , Peter A Fasching _{12,

13} , Matthias W Beckmann ₁₂ , Manuela Gago-Dominguez _{14,

15} , Jose E Castelao ₁₆ , Pascal Guénel ₁₇ , Thérèse Truong ₁₇ , Stig E Bojesen _{18,

19,

20} , Henrik Flyger ₂₁ , Hermann Brenner _{22,

23,

24} , Volker Arndt ₂₂ , Hiltrud Brauch _{24,

25,

26} , Thomas Brüning ₂₇ , Arto Mannermaa _{28,

29,

30} , Veli-Matti Kosma _{28,

29,

30} , Diether Lambrechts _{31,

32} , Machteld Keupers ₃₃ , Fergus J Couch ₃₄ , Celine Vachon ₃₅ , Graham G Giles _{5,

6} , Robert J MacInnis _{5,

6} , Jonine Figueroa _{9,

36} , Louise Brinton ₉ , Kamila Czene ₃₇ , Judith S Brand ₃₇ , Marike Gabrielson ₃₇ , Keith Humphreys ₃₇ , Angela Cox ₃₈ , Simon S Cross ₃₉ , Alison M Dunning ₄₀ , Nick Orr ₄₁ , Anthony Swerdlow _{4,

41} , Per Hall ₃₇ , Paul D P Pharoah _{7,

40} , Marjanka K Schmidt _{11,

42} , Douglas F Easton _{7,

40} , Nilanjan Chatterjee _{9,

43,

44} , Jenny Chang-Claude _{1,

45} , Montserrat García-Closas ₉

Affiliation

Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany.
Real World Insights, CESE, QuintilesIMS, Frankfurt, Germany.
Department of Statistics, Sookmyung Women's University, Seoul, Korea.
Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK.
Cancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, VIC, Australia.
Centre for Epidemiology and Biostatistics, University of Melbourne, Melbourne, VIC, Australia.
Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK.
Department of Electron Microscopy/Molecular Pathology, Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus.
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Department of Pathology, University of Melbourne, Melbourne, VIC, Australia.
Division of Molecular Pathology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany.
David Geffen School of Medicine, Division of Hematology and Oncology, University of California at Los Angeles, Los Angeles, CA, USA.
Genomic Medicine Group, Galician Foundation of Genomic Medicine, Instituto de Investigación Sanitaria de Santiago, IDIS, Complejo Hospitalario Universitario de Santiago, Santiago de Compostela, Spain.
Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.
Oncology and Genetics Unit, Complejo Hospitalario Universitario de Vigo, Instituto de Investigacion Sanitaria Galicia Sur, Vigo, Spain.
Center for Research in Epidemiology and Population Health, University Paris-Sud, University Paris-Saclay, Villejuif, France.
Copenhagen General Population Study.
Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.
Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Department of Breast Surgery, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.
Division of Clinical Epidemiology and Aging Research.
Division of Preventive Oncology, National Center for Tumor Diseases (NCT).
German Cancer Consortium, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany.
Department of Clinical Pharmacology, University of Tübingen, Tübingen, Germany.
Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum, Germany.
Translational Cancer Research Area.
Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland.
Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland.
VIB Center for Cancer Biology, Leuven, Belgium.
Laboratory for Translational Genetics, University of Leuven, Leuven, Belgium.
Department of Radiation Oncology, University Hospitals Leuven, Leuven, Belgium.
Department of Laboratory Medicine and Pathology.
Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Department of Oncology and Metabolism.
Department of Neuroscience, University of Sheffield, Sheffield, UK.
Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK.
Division of Breast Cancer Research, Institute of Cancer Research, London, UK.
Division of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
Bloomberg School of Public Health.
Department of Oncology, Johns Hopkins University, Baltimore, MD, USA.
University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Polygenic risk scores (PRS) for breast cancer can be used to stratify the population into groups at substantially different levels of risk. Combining PRS and environmental risk factors will improve risk prediction; however, integrating PRS into risk prediction models requires evaluation of their joint association with known environmental risk factors.

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