Identification of the Biosynthetic Gene Cluster for Himeic Acid A: A Ubiquitin‐Activating Enzyme (E1) Inhibitor in Aspergillus japonicus MF275,ChemBioChem

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Identification of the Biosynthetic Gene Cluster for Himeic Acid A: A Ubiquitin‐Activating Enzyme (E1) Inhibitor in Aspergillus japonicus MF275
ChemBioChem ( IF 2.6 ) Pub Date : 2018-02-06 , DOI: 10.1002/cbic.201700584
Makoto Hashimoto ₁ , Hikaru Kato ₂ , Ayako Katsuki ₂ , Sachiko Tsukamoto ₂ , Isao Fujii ₁

Affiliation

Fishing for inhibitors: Himeic acid A, which is produced by the marine fungus A. japonicus MF275, is a specific inhibitor of the ubiquitin‐activating enzyme E1 in the ubiquitin–proteasome system. The biosynthesis of himeic acid A in A. japonicus MF275 has been clarified by feeding experiments and the analysis of himA PKS‐NRPS gene disruption.

中文翻译：

庚二酸A的生物合成基因簇的鉴定：日语曲霉MF275中的泛素激活酶（E1）抑制剂。

捕捞抑制剂：由海生真菌A. japonicus MF275产生的组氨酸A是泛素-蛋白酶体系统中泛素激活酶E1的特异性抑制剂。通过进食实验和对himA PKS-NRPS基因破坏的分析，澄清了日本根瘤菌MF275中的山him酸A的生物合成。

更新日期：2018-02-06

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