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Total Synthesis of Two 8‐Oxoprotoberberine Alkaloids: Alangiumkaloids A and B
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2018-02-06 , DOI: 10.1002/ejoc.201701557
Takashi Nishiyama 1 , Miharu Hironaka 1 , Mizuki Taketomi 1 , Eri Taguchi 1 , Rika Kotouge 1 , Yoshiyuki Shigemori 1 , Noriyuki Hatae 2 , Minoru Ishikura 2 , Tominari Choshi 1
Affiliation  

We describe the details of the first total synthesis of alangiumkaloids A (1) and B (2) through construction of an isoquinolinone framework formed by thermal cyclization of 2‐alkynylbenzaldehyde oxime to produce isoquinoline N‐oxide, followed by a Reissert–Henze‐type reaction.
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中文翻译:

两种8-氧代小ber碱生物碱的总合成:lang兰碱A和B

我们通过构造异喹啉酮骨架(由2-炔基苯甲醛肟热环化生成异喹啉N-氧化物,然后再形成Reissert-Henze型)形成异喹啉酮骨架,描述了首个总合成Alangiumkaloids A(1)和B(2)的细节。反应。
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更新日期:2018-02-06
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