Metal-based non-enzymatic sensors have been intensively explored for rapid and efficient detection of biological molecules. Here, we demonstrate the facile assembly of NiMn-layered double hydroxide (NiMn-LDH) on graphene oxide (GO) (NiMn-LDH/GO) for sugars and hydrogen peroxide (H₂O₂) monitoring. The hybrids can be easily and large-scale prepared via a simple co-precipitation and hydrothermal approach. Under optimal preparation conditions, NiMn-LDH/GO hybrids exhibit a remarkable sensitivity for glucose oxidation (839.2 μA mM⁻¹ cm⁻²) and H₂O₂ reduction (96.82 μA mM⁻¹ cm⁻²), along with a low detection limit of 1.2 μM and 4.4 μM, respectively. With regard to glucose detection, the linear response range covered four orders of magnitude from 2 μM to 3.386 mM with a correlation coefficient of 0.998. Such versatile sensor is also suitable for detecting other sugars (sucrose, mannitol and erythritol). The delicate non-enzymatic sensor possessed rapid response (reach to ready-state in less than 10 s), good selectivity and reproducibility toward sugars and H₂O₂ detection, which will boost the exploration of layered metallic nanomaterials in electrochemical sensors.

已经对基于金属的非酶传感器进行了深入研究，以快速有效地检测生物分子。在这里，我们展示了用于糖和过氧化氢（H ₂ O ₂）监测的NiMn层状双氢氧化物（NiMn-LDH）在氧化石墨烯（GO）（NiMn-LDH / GO）上的简便组装。可以通过简单的共沉淀和水热方法轻松，大规模地制备杂种。在最佳制备条件，的NiMn-LDH / GO杂种表现出对葡萄糖氧化（839.2毫μA一个显着的灵敏度^-1 厘米^-2）和H ₂ ö ₂减少（96.82毫μA ^-1 厘米^-2），以及分别为1.2μM和4.4μM的低检测限。关于葡萄糖检测，线性响应范围涵盖了从2μM到3.386 mM的四个数量级，相关系数为0.998。这种多功能传感器还适用于检测其他糖类（蔗糖，甘露糖醇和赤藓糖醇）。精致的非酶传感器具有快速响应（在不到10 s内即可达到就绪状态），对糖和H ₂ O ₂检测的良好选择性和重现性，这将促进电化学传感器中层状金属纳米材料的探索。