The overarching goal of the KARMA (KARolinska MAmmography Project for Risk Prediction of Breast Cancer) study is to reduce the incidence and mortality of breast cancer by focusing on individualized prevention and screening (Figure 1). The primary objectives of the KARMA study are: (i) to determine the roles and interaction of mammographic density, genetic determinants and lifestyle in the risk of breast cancer through a large-scale population cohort study; (ii) to build a comprehensive risk prediction model including all known and established risk factors for breast cancer; (iii) to discover new biomarkers for early detection and prevention of breast cancer using genomic and proteomic approaches; and (iv) to establish a comprehensive database of information linked to biological specimens, which will become a resource for further scientific studies.

中文翻译：

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队列资料：乳腺癌风险预测的Karolinska乳腺摄影项目（KARMA）

KARMA（KARolinska乳腺X线照相术对乳腺癌的风险预测）研究的总体目标是通过注重个体化的预防和筛查来降低乳腺癌的发病率和死亡率（图1）。KARMA研究的主要目标是：（i）通过大规模人群研究确定乳腺钼靶密度，遗传决定因素和生活方式在乳腺癌风险中的作用和相互作用；（ii）建立一个全面的风险预测模型，其中包括所有已知的和已确定的乳腺癌风险因素；（iii）利用基因组学和蛋白质组学方法发现新的生物标记物，用于乳腺癌的早期发现和预防；（iv）建立与生物标本有关的综合信息数据库，这将成为进一步科学研究的资源。