Pancreatic cancer, a high-burden cancer, is the 12th most common cancer and the seventh most common cause of cancer death globally.¹ The accurate diagnosis of this internal malignancy is challenging in settings without access to medical imaging technology. Around 20–50% of cases are diagnosed only clinically, without microscopic assessment of a tissue sample. In 2012, the average age-standardized incidence and mortality rates in developed countries were 8.6 and 8.3 per 100‐000, respectively, in men and 5.9 and 5.5 per 100‐000, respectively, in women.¹ As these rates suggest, relative survival is very poor, around 5–10% at 5 years.^2,3 With an aggressive natural history, indistinct symptoms and no effective screening test or therapy, primary prevention is currently the best available strategy to reduce the burden of this malignancy....

中文翻译：

---

评论：异常胰腺癌的发病率和死亡率模式

胰腺癌是高负担的癌症，是全球第12大最常见的癌症和第七大最常见的癌症死亡原因。¹在无法获得医学影像技术的情况下，对这种内部恶性肿瘤的准确诊断非常困难。大约20–50％的病例仅在临床上得到诊断，而没有对组织样本进行显微镜评估。2012年，发达国家的平均年龄标准化发病率和死亡率分别为男性每十万分之8.6和8.3，男性和女性每十万分之5.9和5.5。¹正如这些比率所表明的，相对存活率非常低，在5年时约为5-10％。^{2 ，3} 具有侵略性的自然病史，症状不明显且没有有效的筛查测试或疗法，一级预防目前是减轻这种恶性肿瘤负担的最佳可行策略。