Lagunamide C is a depsipeptide natural product with low nM cytotoxicity towards numerous cancer cell lines. Synthetically, it is disconnected to a pentapeptide backbone and polyketide unit that possesses four stereogenic centers, of which two of centers are in question (C38 & 40). Our model system highlights a high-selective aldol addition via a Crimmin’s auxiliary setting the C40 ester linkage, and a non-facially selective cyclopropanation with subsequent ring opening for the installation of the C38 methyl center.

中文翻译：

---

Lagunamide C的合成研究：聚酮化合物的组装研究

Lagunamide C是一种十肽天然产物，对多种癌细胞具有低nM细胞毒性。综合而言，它与拥有四个立体生成中心的五肽主链和聚酮化合物单元断开连接，其中两个中心存在问题（C38和40）。我们的模型系统突出显示了通过Crimmin的辅助设置C40酯键进行的高选择性羟醛加成，以及非表面选择性的环丙烷化以及随后的C38甲基中心安装的开环。