Parasite infection in the intestine can lead to inflammatory immune cells in the lung Innate lymphoid cells (ILCs) are a type of immune cell that are considered to be tissue-resident gatekeepers situated in mucosal membranes, where they contribute to both homeostasis and pathology (1). In healthy individuals, ILCs are involved in tissue repair, but ILCs have also been shown to participate in several types of inflammation, including allergy and asthma. Whereas ILCs can be found at low frequencies in the blood circulation, mucosal barriers such as the intestine and airways are enriched for ILCs (1). However, whether ILCs are in fact tissue resident in the sense that they self-renew without substantial replenishment from other organs has been a topic of debate. The mechanisms of ILC circulation are important for understanding various types of inflammatory conditions and how they can be treated. On page 114 of this issue, Huang et al. (2) demonstrate that ILC2s are not obligate tissue-resident cells because they can be recruited from the gut to the lung and other organs in response to inflammatory signaling.

中文翻译：

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源自肠道的肺部炎症

肠道寄生虫感染可导致肺中的炎症免疫细胞 先天淋巴细胞 (ILC) 是一种免疫细胞，被认为是位于粘膜中的组织驻留守门人，在那里它们有助于体内平衡和病理学 (1 ）。在健康个体中，ILCs 参与组织修复，但 ILCs 也被证明参与多种类型的炎症，包括过敏和哮喘。虽然 ILC 在血液循环中的频率较低，但黏膜屏障（如肠和气道）富含 ILC (1)。然而，在没有其他器官大量补充的情况下，ILCs 是否实际上是组织驻留的，这是一个有争议的话题。ILC 循环的机制对于了解各种类型的炎症以及如何治疗它们很重要。在本期第 114 页，Huang 等人。(2) 证明 ILC2 不是专性组织驻留细胞，因为它们可以响应炎症信号从肠道募集到肺和其他器官。