Two key findings of the AMAZES trial¹ are relevant to asthma management. First, the addition of low-dose azithromycin to a combination of inhaled corticosteroids and long-acting bronchodilators led to a clinically significant reduction in asthma exacerbations in adults with poorly controlled asthma. This finding provides an additional therapeutic option for these patients. Second, the effect occurred equally in both eosinophilic and non-eosinophilic asthma, by an as yet unidentified mechanism, but acting on pathways other than type 2 inflammation.

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阿奇霉素如何改善哮喘发作？–作者的答复

AMAZES试验^1的两个关键发现与哮喘的治疗有关。首先，将低剂量阿奇霉素添加到吸入皮质类固醇和长效支气管扩张剂的组合中，可导致哮喘控制较差的成人哮喘急性发作的临床显着减少。这一发现为这些患者提供了额外的治疗选择。其次，该作用在嗜酸性和非嗜酸性哮喘中均发生，但尚不明确，其机制与除2型炎症外的其他途径有关。