Nuclear receptor (NR) genes form a conserved superfamily, which is involved in organism metabolism, reproduction, development, homeostasis, and resource allocation. Microcystis aeruginosa can inhibit the growth and reproduction of Daphnia. However, whether M. aeruginosa can affect the expression of Daphnia NR genes is unknown. In total, 18 NRs were identified in this study based on previous Daphnia similoides sinensis transcriptome data. In treatments containing M. aeruginosa, the gene expression of the NR1 subfamily (E75a, E75b, HR3, HR96, NHR-1, HR97a, HR97g, and NHR97) and the NR2 subfamily (RXR, TLL, PNR, and SVP) were down-regulated 59% and 79%, respectively. In treatments containing M. aeruginosa, although the expression of 78% of the genes showed a similar trend in clones 1 and 2, the expression of 42% of the genes in clone 3 showed the opposite trend compared to clones 1 and 2, suggesting that the adaptability and molecular mechanism differ in individuals with different Microcystis tolerance genotypes.

核受体（NR）基因形成一个保守的超家族，涉及生物代谢，繁殖，发育，体内稳态和资源分配。铜绿微囊藻可以抑制水蚤的生长和繁殖。但是，铜绿假单胞菌是否可以影响水蚤NR基因的表达尚不清楚。根据先前的水蚤（Daphnia similoides sinensis）转录组数据，本研究总共鉴定出18个NR 。在含有铜绿假单胞菌的治疗中，NR1亚家族（E75a，E75b，HR3，HR96，NHR-1，HR97a，HR97g和NHR97）和NR2亚家族（RXR，TLL，PNR和SVP）的基因表达下调了59％和79 ％， 分别。在含铜绿假单胞菌的处理中，尽管克隆1和2中78％的基因表达呈现相似趋势，但克隆3和克隆1和2中42％的基因表达呈现相反趋势，这表明具有不同微囊藻耐受性基因型的个体的适应性和分子机制也不同。