A ruthenium–prolinamide catalytic system has been applied for the first time in dynamic kinetic resolution/asymmetric transfer hydrogenation reactions (DKR/ATH) in aqueous medium to synthesize cis‐β‐heterosubstituted cycloalkanols with two contiguous chiral centers. The effect of various prolinamide ligands in DKR/ATH has been studied on different racemic‐β‐heterosubstituted cycloalkanones. A prolinamide ligand with a bulky substituent at an ortho position proves to be more effective than the previously reported ruthenium–TsDPEN catalytic system in aqueous medium, producing up to 99.1 % enantioselectivity and 99:1 diastereoselectivity.

中文翻译：

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动态动力学拆分驱动Ru-脯氨酰胺催化外消旋β-杂取代环烷酮的不对称转移加氢

钌-脯氨酰胺催化体系首次在水介质中用于动态动力学拆分/不对称转移氢化反应（DKR / ATH）中，以合成具有两个连续手性中心的顺式-β-杂取代环烷醇。研究了DKR / ATH中各种脯氨酰胺配体对不同外消旋-β-杂取代的环烷酮的影响。在水性介质中，在邻位具有较大取代基的脯氨酰胺配体被证明比先前报道的钌-TsDPEN催化体系更有效，对映选择性高达99.1％，非对映选择性高达99：1。