The bone marrow (BM) niche is a complex microenvironment that supports healthy hematopoietic stem cells (HSCs) throughout life. In this issue of Cell Stem Cell, Duarte et al. (2018) reveal the spatio-temporal progress of leukemic cells as they invade and occupy the niche, ultimately outcompeting native HSCs.

中文翻译：

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咀嚼根：白血病如何侵入和破坏骨髓微环境。

骨髓（BM）生态位是一个复杂的微环境，在整个生命过程中都支持健康的造血干细胞（HSC）。在本期《细胞干细胞》中，Duarte等人。（2018）揭示了白血病细胞入侵并占据利基市场时空的进展，最终胜过了天然HSC。