Minority subpopulations within embryonic stem cell cultures display an expanded developmental potential similar to that of early embryo blastomeres or the early inner cell mass. The ability to isolate and culture totipotent cells capable of giving rise to the entire conceptus would enhance our capacity to study early embryo development, and might enable more efficient generation of chimeric animals for research and organ production for transplantation. Here we review the biological and molecular characterization of cultured cells with developmental potential similar to totipotent blastomeres, and assess recent progress toward the capture and stabilization of the totipotent state in vitro.

中文翻译：

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捕获全能干细胞。

胚胎干细胞培养物中的少数亚群显示出与早期胚胎卵裂球或早期内部细胞团相似的扩展的发展潜力。分离和培养能够产生整个概念的全能细胞的能力将增强我们研究早期胚胎发育的能力，并可能使嵌合动物的研究和器官生产的移植更有效。在这里，我们审查具有与全能卵裂球相似的发展潜力的培养细胞的生物学和分子表征，并评估在体外全能状态的捕获和稳定方面的最新进展。