Embolization is a nonsurgical, minimally invasive procedure that deliberately blocks a blood vessel. Although several embolic particles have been commercialized, their much wider applications have been hampered owing mainly to particle size variation and uncontrollable degradation kinetics. Herein we introduce a microfluidic approach to fabricate highly monodisperse gelatin microparticles (GMPs) with a microshell structure. For this purpose, we fabricate uniform gelatin emulsion precursors using a microfluidic technique and consecutively cross-link them by inbound diffusion of glutaraldehyde from the oil continuous phase to the suspending gelatin precursor droplets. A model micromechanic study, carried out in an artificial blood vessel, demonstrates that the extraordinary degradation kinetics of the GMPs, which stems from the microshell structure, enables controlled rupturing while exhibiting drug release under temporary chemoembolic conditions

中文翻译：

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单分散微壳结构明胶微粒的临时化学栓塞。

栓塞是一种非手术，微创手术，有意阻塞​​血管。尽管几种栓塞颗粒已经商品化，但由于粒径变化和不可控制的降解动力学，阻碍了它们的广泛应用。本文中，我们介绍了一种微流体方法来制造具有微壳结构的高度单分散的明胶微粒（GMP）。为此，我们使用微流体技术制造了均匀的明胶乳液前体，并通过戊二醛从油连续相到悬浮的明胶前体液滴的向内扩散，使它们连续交联。在人造血管中进行的模型微力学研究表明，GMP的非凡降解动力学源于微壳结构，